pentobarbital raises toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Lively alkylating metabolites.
pentobarbital will decrease the extent or influence of etonogestrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will lower the extent or result of eletriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will lessen the extent or effect of duvelisib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration with a powerful CYP3A inducer decreases duvelisib place under the curve (AUC), which may lower duvelisib efficacy.
The influence of the resultant lessened blood amounts of griseofulvin on therapeutic reaction has not been established. Having said that, It might be preferable to stop concomitant administration of those medication.
pentobarbital will lower the extent or result of darunavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Griseofulvin: Phenobarbital seems to interfere Using the absorption of orally administered griseofulvin, Therefore lowering its blood amount.
In a broadcast study, administration of an anesthetic dose of ketamine for twenty-four several hours on Gestation Day 122 improved neuronal apoptosis while in the creating Mind of the fetus. In other released studies, administration of both isoflurane or propofol for five hours on Gestation Day one hundred twenty resulted in improved check here neuronal and oligodendrocyte apoptosis while in the creating Mind with the offspring.
pentobarbital will reduce the level or result of armodafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.
Estradiol, estrone, progesterone and other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital may lessen the impact of estradiol by raising its metabolism.
pentobarbital will lower the level or impact of bazedoxifene/conjugated estrogens by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Phenobarbital sodium is carcinogenic in mice and rats following lifetime administration. In mice, it created benign and malignant liver mobile tumors. In rats, benign liver cell tumors ended up noticed quite late in life.
The above info is meant to complement, not substitute for, the experience and judgment of one's well being treatment Expert. You need to speak to your wellness treatment professional prior to using any drug, Altering your diet program, or commencing or discontinuing any course of treatment.
pentobarbital will minimize the extent or influence of sunitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.